Wissenschaftliche Publikationen

WISSENSCHAFTLICHE REFERENZEN - EINFLUSS DER TOXINE AUF DEN MENSCHEN UND INUSPHERESE ®

HIGHLY PROCESSED DIET

1. Nogacka AM, Gómez-Martín M, Suárez A, González-Bernardo O, de Los Reyes-Gavilán CG, González S. Xenobiotics Formed during Food Processing: Their Relation with the Intestinal Microbiota and Colorectal Cancer. Int J Mol Sci. 2019;20(8):2051. Published 2019 Apr 25. doi:10.3390/ijms20082051

INSUFFICIENT PROTEIN

2. Hou Y, Yin Y, Wu G. Dietary essentiality of "nutritionally non-essential amino acids" for animals and humans. Exp Biol Med (Maywood). 2015;240(8):997-1007. doi:10.1177/1535370215587913

NUTRITION

3. Hoffman J, Hennig B. Protective influence of healthful nutrition on mechanisms of environmental pollutant toxicity and disease risks. Annals of the New York Academy of Sciences. 1398(1),2017. https://doi.org/10.1111/nyas.13365

GUT DYSBIOSIS

4. Rosenfeld C. Gut Dysbiosis in Animals Due to Environmental Chemical Exposures. Front Cell Infect Microbiol.2017;7:396. doi: 10.3389/fcimb.2017.00396.

5. Claus S, Guillou H, Ellero-Simatos S. The Gut Microbiotica: A Major Player in the Toxicity of Environmental Pollutants? NPJ Biofilms Microbiomes. 2016;2:16003. doi: 10.1038/npjbiofilms.2016.3

GENETIC VARIATIONS/SNPs

6. Marin, J.J.G.; Serrano, M.A.; Monte, M.J.; Sanchez-Martin, A.; Temprano, A.G.; Briz, O.; Romero, M.R. Role of Genetic Variations in the Hepatic Handling of Drugs. Int. J. Mol. Sci. 2020, 21, 2884

7. Bukowski K, Woźniak K. Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticides. Med Pr. 2018;69(2):225-235. doi:10.13075/mp.5893.00595

8. Goetz MP, Suman VJ, Hoskin TL, Gnant M, Filipits M, Safgren SL, Kuffel M, Jakesz R, Rudas M, Greil R, Dietze O, Lang A, Offner F, Reynolds CA, Weinshilboum RM, Ames MM, Ingle JN. CYP2D6 metabolism and patient outcome in the Austrian Breast and Colorectal Cancer Study Group trial (ABCSG) 8. Clin Cancer Res. 2013 Jan 15;19(2):500-7. doi: 10.1158/1078-0432.CCR-12-2153.

STRESS/EMOTIONAL TRAUMA

9. Deng Q, Deng L, Lu C, Li Y, Norbäck D. Parental stress and air pollution increase childhood asthma in China. Environ Res. 2018;165:23-31. doi:10.1016/j.envres.2018.04.003

NUTRIENT DEFICIENCIES

10. Miller CN, Rayalam S. The role of micronutrients in the response to ambient air pollutants: Potential mechanisms and suggestions for research design. J Toxicol Environ Health B Crit Rev. 2017;20(1):38-53. doi:10.1080/10937404.2016.1261746

11. Baccarelli A, Cassano PA, Litonjua A, et al. Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. Circulation. 2008;117(14):1802-1809. doi:10.1161/CIRCULATIONAHA.107.726067

ONGOING EXPOSURES AND INCREASED RISK OF MORTALITY AND CHRONIC DISEASE

12. Bauleo L, Bucci S, Antonucci C, et al. Long-term exposure to air pollutants from multiple sources and mortality in an industrial area: a cohort study. Occup Environ Med. 2019;76(1):48-57. doi:10.1136/oemed-2018-105059

FURTHER EVIDENCE LITERATURE:

1. Rappaport SM. Implications of the exposome for exposure science. J Expo Sci Environ Epidemiol. 2011 Jan-Feb;21(1):5-9. doi: 10.1038/jes.2010.50.

2. Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy Metals Toxicity and the Environment. EXS. 2012;101:133-164. doi:10.1007/978-3-7643-8340-4_6.

3. Verner MA, Ayotte P, Muckle G, Charbonneau M, Haddad S. A physiologically based pharmacokinetic model for the assessment of infant exposure to persistent organic pollutants in epidemiologic studies [published correction appears in Environ Health Perspect. 2013 Jul;121(7):A209]. Environ Health Perspect. 2009;117(3):481-487. doi:10.1289/ehp.0800047 (Source for Table 3)

4. Brenner G, Stevens C. Pharmacology. Philadelphia, PA: Elsevier/Saunders; 2013:23-25

5. Thornton JW, McCally M, Houlihan J. Biomonitoring of industrial pollutants: health and policy implications of the chemical body burden. Public Health Rep. 2002 Jul-Aug;117(4):315-23.

6. Pumarega J, Gasull M, Lee DH, López T, Porta M. Number of Persistent Organic Pollutants Detected at High Concentrations in Blood Samples of the United States Population. PLoS One. 2016 Aug 10;11(8):e0160432. doi: 10.1371/journal.pone.0160432.

7. DellaValle C. The Pollution in People: Cancer-Causing Chemical in Americans’ Bodies. Environmental Working Group Original Research. EWG website. https://static.ewg.org/reports/2016/cancer_main/the-pollution-in- people/EWG_Cancer_Bio-Monitoring_Report_C02-pages.pdf.

8. Wilding BC, Curtis K, Welker-Hood K. Hazardous Chemicals in Health Care: A Snapshot of Chemicals in Doctors and Nurses. Physicians for Social Responsibility. https://www.psr.org/blog/resource/hazardous-chemicals- in-health-care/. Published October 7, 2009.

9. Verner MA, Charbonneau M, López-Carrillo L, Haddad S. Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies. Environ Health Perspect. 2008 Jul;116(7):886-92. doi: 10.1289/ehp.10917

10. Verner MA, Charbonneau M, López-Carrillo L, Haddad S. Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies. Environ Health Perspect. 2008 Jul;116(7):886-92. doi: 10.1289/ehp.10917

11. Menegon A, Board PG, Blackburn AC, Mellick GD, Le Couteur DG. Parkinson's disease, pesticides, and glutathione transferase polymorphisms. Lancet. 1998 Oct 24;352(9137):1344-6.

WISSENSCHAFTLICHE STUDIEN ZUR INUSphesese ®

1. Stefan R. Bornstein1, 2, 3, 4, Karin Voit-Bak5, Dieter Schmidt5, Henning Morawietz6, Alexander Benjamin Bornstein2, Waldimir Balanzew2, Ulrich Julius2, Roman N. Rodionov2, Anne Maria Biener2, Jun Wang2, Klaus-Martin Schulte7, 8, Peter Krebs9, Günter Vollmer10, R. Straube5, Is There a Role for Environmental and Metabolic Factors Predisposing to Severe COVID-19?, DOI https://doi.org/10.1055/a-1182-2016 Published online: 29.6.2020, Horm Metab Res 2020; 52: 540–546, © Georg Thieme Verlag KG Stuttgart · New York ISSN 0018-5043

2. Stefan R. Bornstein1,2, 3, Karin Voit-Bak 4 •Peter Rosenthal 5• Sergey Tselmin 1 •Ulrich Julius1 •Ulrike Schatz 1. Bernhard O. Boehm®• Sandrine Thuret 7•Gerd Kempermann 8,9 •Heinz Reichmann 10 •George P. Chrousos 1,11 Julio Licinio12. Ma-Li Wong 12 . Andrew V. Schally 13,14 . Richard Straube 4, Extracorporeal apheresis therapy for Alzheimer disease--targeting lipids, stress, and inflammation, Accepted: 24 September 2019 ©S p r i n g e r Nature Limited 2019, Molecular Psychiatry https://doi.org/10.1038/s41380-019-0542-x

3. Richard Straube 1, Karin Voit-Bak 1, A. Gor 1, Til Steinmeier 1, George P. Chrousos 2, Bernard Otto Böhm, Stefan R. Bornstein 3,5,6,7,9,10, Lipid Profiles in Lyme Borreliosis: A Potential Role for Apheresis?, accepted 26.3.2019, Form Metal Res 2019, 51:326-329, © Georg Thieme Verlag KG Stuttgart · New York ISSN 0018-504

4. Charlotte Steenblock 1, Romy Walther, Sergey Tselmin 1, Stefan R. Bornstein, Roman N. Rodionov 1,2, Post COVID and Apheresis - Where are we Standing, Horn Metal Res, 2022, © Georg Thieme Verlag KG Stuttgart · New York ISSN 0018-5043

5. Straube R, Gäckler D, Thiele A, Muselmann L, Kingreen H, Klingel R. Membrane differential filtration is safe and effective for the long-term treatment of Refsum syndrome--an update of treatment modalities and pathophysiological cognition., Transfus Apher Sci. 2003 Aug;29(1):85-91. doi: 10.1016/S1473-0502(03)00102-2. PMID: 12877898

6. Metabolic and Non-Metabolic Peripheral Neuropathy: Is there a Place for Therapeutic Apheresis?, Straube R, Müller G, Voit-Bak K, Tselmin S, Julius U, Schatz U, Rietzsch H, Reichmann H, Chrousos GP, Schürmann A, Jarc L, Ziemssen T, Siepmann T, Bornstein SR. Horm Metab Res. 2019 Dec;51(12):779-784. doi: 10.1055/a-1039- 1471. Epub 2019 Dec 11. PMID: 31826273 Review.

7. Extracorporeal apheresis therapy for Alzheimer disease-targeting lipids, stress, and inflammation.Bornstein SR, Voit-Bak K, Rosenthal P, Tselmin S, Julius U, Schatz U, Boehm BO, Thuret S, Kempermann G, Reichmann H, Chrousos GP, Licinio J, Wong ML, Schally AV, Straube R. Mol Psychiatry. 2020 Feb;25(2):275-282. doi: 10.1038/s41380-019- 0542-x. Epub 2019 Oct 8. PMID: 31595035 Review.